Safety of Proton Pump Inhibitors in Pediatric Population: A Systematic Review-Reference-Cited by-同舟云学术

Safety of Proton Pump Inhibitors in Pediatric Population: A Systematic Review

Published:2024-01 Issue: Volume:11 Page:
ISSN:2333-794X
Container-title:Global Pediatric Health
language:en
Short-container-title:Global Pediatric Health

Author:

Alla Deekshitha¹^ORCID,Shah Dhruv Jayeshkumar²^ORCID,Seepana Muneesh³,Salian Rishabh Baskara⁴,Alla Sai Santhosha Mrudula¹^ORCID,Krishna Mohanan Midhun⁵,Sabıroğlu Mert⁶,Vegesna Mohan Sai Sunith⁷^ORCID,Singh Aradhya⁸^ORCID,Gupta Srajan⁹,Shivalingappa Rekha Shushrutha¹⁰

Affiliation:

1. Andhra Medical College, Visakhapatnam, Andhra Pradesh, India

2. Massachusetts College of Pharmacy and Health Sciences, Boston, MA, USA

3. Guntur Medical College, Guntur, Andhra Pradesh, India

4. Kasturba Medical College, Mangalore, Karnataka, India

5. Sree Uthradom Thirunal (SUT) Academy of Medical Sciences, Thiruvananthapuram, Kerala, India

6. Koç University School of Medicine, İstanbul, Turkey

7. Jilin University, Changchun, China

8. Spartan Health Sciences University, Vieux Fort, Saint Lucia

9. SVMC, Tirupati, Andhra Pradesh, India

10. Sri Devaraj Urs Medical College, Kolar, Karnataka, India

Abstract

Objective. Commonly recommended drugs for adults and children include proton pump inhibitors (PPIs), proven effective for treating peptic diseases like stomach ulcers, GERD, and Helicobacter pylori infections in children over 1-year-old. Yet, prolonged PPI use carries higher risks of adverse reactions, prompting this study’s analysis. Methods. We have performed a systematic review of 30 articles, which include a total of 762 505 pediatric patients. Results. Adverse effects were encountered in 6.98% of the population. The 5 most common adverse effects were respiratory tract complications, gastrointestinal complications, urinary tract infections, asthma, and ENT infections. Conclusion. Hence, PPIs should be prescribed only when necessary, and physicians should prioritize patient education when considering their use.

Publisher

SAGE Publications

Link

https://journals.sagepub.com/doi/pdf/10.1177/2333794X241248967

Reference57 articles.

1. The Indications, Applications, and Risks of Proton Pump Inhibitors

2. Ahmed A. Proton pump inhibitors (PPI). StatPearls - NCBI Bookshelf. Published May 1, 2023. https://www.ncbi.nlm.nih.gov/books/NBK557385/

3. Proton Pump Inhibitors in Pediatrics

4. Long-Term Proton Pump Inhibitor Use in Children: A Retrospective Review of Safety

5. Pharmacological treatment of children with gastro-oesophageal reflux

Cited by 1 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Long-Term Proton Pump Inhibitor–Acid Suppressive Treatment Can Cause Vitamin B12 Deficiency in Zollinger–Ellison Syndrome (ZES) Patients;International Journal of Molecular Sciences;2024-07-02