The Impact of Methylphenidate on Pubertal Maturation and Bone Age in ADHD Children and Adolescents: Results from the ADHD Drugs Use Chronic Effects (ADDUCE) Project

Author:

Carucci Sara12ORCID,Zuddas Alessandro12,Lampis Angelico3,Man Kenneth K. C.4567,Balia Carla12,Buitelaar Jan48,Danckaerts Marina9,Dittmann Ralf W.10,Donno Federica1,Falissard Bruno11,Gagliano Antonella12,Garas Peter13,Häge Alexander10,Hollis Chris14,Inglis Sarah K.15,Konrad Kerstin1617,Kovshoff Hanna18,Liddle Elizabeth14,McCarthy Suzanne19,Neubert Antje20,Nagy Peter21,Rosenthal Eric22,Sonuga-Barke Edmund J. S.23,Wong Ian C. K.356724,Banaschewski Tobias10,Coghill David1525

Affiliation:

1. University of Cagliari, Italy

2. ASL Cagliari, Italy

3. University College London, UK

4. Donders Institute for Brain, Cognition and Behavior, Nijmegen, The Netherlands

5. Hong Kong Science Park, China

6. University College London Hospitals NHS Foundation Trust, UK

7. The University of Hong Kong, China

8. Karakter Child and Adolescent Psychiatry University Centre, Nijmegen, The Netherlands

9. University Psychiatric Center KU Leuven, Belgium

10. University of Heidelberg, Mannheim, Germany

11. Université Paris-Saclay, France

12. University of Messina, Italy

13. Semmelweis University, Budapest, Hungary

14. University of Nottingham, UK

15. University of Dundee, UK

16. University Hospital RWTH Aachen, Germany

17. RWTH Aachen and Research Centre Jülich, Germany

18. University of Southampton, UK

19. University College Cork, Ireland

20. Universitätsklinikum Erlangen, Germany

21. Bethesda Children’s Hospital, Budapest, Hungary

22. Evelina London Children’s Hospital, UK

23. King’s College London, UK

24. Aston University, Birmingham, UK

25. University of Melbourne, VIC, Australia

Abstract

Objective: The short-term safety of methylphenidate (MPH) has been widely demonstrated; however the long-term safety is less clear. The aim of this study was to investigate the safety of MPH in relation to pubertal maturation and to explore the monitoring of bone age. Method: Participants from ADDUCE, a two-year observational longitudinal study with three parallel cohorts (MPH group, no-MPH group, and a non-ADHD control group), were compared with respect to Tanner staging. An Italian subsample of medicated-ADHD was further assessed by the monitoring of bone age. Results: The medicated and unmedicated ADHD groups did not differ in Tanner stages indicating no higher risk of sexual maturational delay in the MPH-treated patients. The medicated subsample monitored for bone age showed a slight acceleration of the bone maturation after 24 months, however their predicted adult height remained stable. Conclusion: Our results do not suggest safety concerns on long-term treatment with MPH in relation to pubertal maturation and growth.

Funder

EU Seventh Framework Programme for research for research, technological development and demonstration

Publisher

SAGE Publications

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