Influence of GABA<sub>A</sub> and GABA<sub>B</sub> receptor activation on auditory sensory gating and its association with anxiety in healthy volunteers-Reference-Cited by-同舟云学术

Influence of GABA_A and GABA_B receptor activation on auditory sensory gating and its association with anxiety in healthy volunteers

Published:2024-04-22 Issue:6 Volume:38 Page:532-540
ISSN:0269-8811
Container-title:Journal of Psychopharmacology
language:en
Short-container-title:J Psychopharmacol

Author:

de la Salle Sara¹²,Piche Justin³^ORCID,Duncan Brittany⁴,Choueiry Joëlle¹³^ORCID,Hyde Molly⁵,Aidelbaum Robert⁶,Baddeley Ashley¹,Impey Danielle²,Rahmani Noreen²,Ilivitsky Vadim⁷,Knott Verner¹³^ORCID

Affiliation:

1. The Royal’s Institute of Mental Health Research at The Royal, Ottawa, ON, Canada

2. School of Psychology, University of Ottawa, Ottawa, ON, Canada

3. Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, ON, Canada

4. Department of Psychology, Carleton University, Ottawa, ON, Canada

5. Institute of Medical Science, University of Toronto, Toronto, ON, Canada

6. School of Psychology, University of Toronto, Toronto, ON, Canada

7. The Royal Ottawa Mental Health Centre, Ottawa, ON, Canada

Abstract

Background: Dysfunctional sensory gating in anxiety disorders, indexed by the failure to inhibit the P50 event-related potential (ERP) to repeated stimuli, has been linked to deficits in the major inhibitory neurotransmitter γ-aminobutyric acid (GABA). Aims/Methods: This study, conducted in 30 healthy volunteers, examined the acute effects of GABAA (lorazepam: 1 mg) and GABAB receptor (baclofen: 10 mg) agonists on P50 measures of auditory sensory gating within a paired-stimulus (S1-S2) paradigm and assessed changes in gating in relation to self-ratings of anxiety. Results: Compared to placebo, lorazepam reduced ERP indices of sensory gating by attenuating response to S1. Although not directly impacting P50 inhibition, baclofen-induced changes in gating (relative to placebo) were negatively correlated with trait but not state anxiety. Conclusions: These preliminary findings support the involvement of GABA in sensory gating and tentatively suggest a role for GABAB receptor signaling in anxiety-associated gating dysregulation.

Funder

National Sciences and Engineering Research Council

Publisher

SAGE Publications

Link

https://journals.sagepub.com/doi/pdf/10.1177/02698811241246854

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