Systemic mazindol reduces food intake in rats via suppression of meal size and meal number-Reference-Cited by-同舟云学术

Systemic mazindol reduces food intake in rats via suppression of meal size and meal number

Published:2008-02-28 Issue:5 Volume:22 Page:532-535
ISSN:0269-8811
Container-title:Journal of Psychopharmacology
language:en
Short-container-title:J Psychopharmacol

Author:

Wellman PJ¹

Affiliation:

1. Behavioral Neuroscience Program, Department of Psychology, Texas A&M University, College Station, TX, USA,

Abstract

The aim of the present study was to determine the impact of the appetite suppressant mazindol on meal pattern in rats. Meal patterns were monitored in adult male rats after mazindol dosing during the first three hours of the dark cycle using automated feeding chambers (BioDAQ). Mazindol (0, 0.25, 1.25 and 2.5 mg/kg, IP) produced a dose-dependent hypophagia and hypodipsia. Meal size and meal number were significantly suppressed by mazindol. The meal pattern findings indicate that mazindol inhibits eating in the rat via a suppression of both meal size and meal number.

Publisher

SAGE Publications

Subject

Pharmacology (medical),Psychiatry and Mental health,Pharmacology

Link

http://journals.sagepub.com/doi/pdf/10.1177/0269881107083837

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