Epitopes on β2-GPI recognized by anticardiolipin antibodies-Reference-Cited by-同舟云学术

Epitopes on β2-GPI recognized by anticardiolipin antibodies

Published:1998-02 Issue:2_suppl Volume:7 Page:14-17
ISSN:0961-2033
Container-title:Lupus
language:en
Short-container-title:Lupus

Author:

Koike T¹,Ichikawa K¹,Kasahara H¹,Atsumi T¹,Tsutsumi A¹,Matsuura E²

Affiliation:

1. Department of Medicine II, Hokkaido University School of Medicine, Sapporo Japan

2. Department of Cell Chemistry, Institute of Molecular and Cellular Biology, Okayama University Medical School, Okayama, Japan

Abstract

Anticardiolipin antibodies (aCL) found in sera from patients with antiphospholipid syndrome recognize a cryptic epitope that appears on the β2-glycoprotein I (β2-GPI) molecule when β2-GPI interacts with a lipid membrane composed of negatively charged phospholipid or when β2-GPI is adsorbed on a polyoxygenated polystyrene plate. A homology based model of β2-GPI was constructed based on the NMR coordinates of sushi domains of human factor H. The conformation was like a cylinder consisting of five domains, its IV and V domains being glued by electrostatic interaction. We used phage-displayed random peptide libraries to search the epitopes of human aCL. Structures similar to consensus sequences selected by a biopanning method was found on domain IV of β2-GPI.

Publisher

SAGE Publications

Subject

Rheumatology

Link

http://journals.sagepub.com/doi/pdf/10.1177/096120339800700204

Reference33 articles.

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3. Anticardiolipin antibodies (ACA) directed not to cardiolipin but to a plasma protein cofactor

4. Anticardiolipin cofactor(s) and differential diagnosis of autoimmune disease

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