Magnesium and Fracture Risk in the General Population and Patients Receiving Dialysis: A Narrative Review-Reference-Cited by-同舟云学术

Magnesium and Fracture Risk in the General Population and Patients Receiving Dialysis: A Narrative Review

Published:2023-01 Issue: Volume:10 Page:205435812311541
ISSN:2054-3581
Container-title:Canadian Journal of Kidney Health and Disease
language:en
Short-container-title:Can J Kidney Health Dis

Author:

Cowan Andrea C.¹^ORCID,Clemens Kristin K.²,Sontrop Jessica M.³^ORCID,Dixon Stephanie N.³⁴^ORCID,Killin Lauren⁵,Anderson Sierra⁵,Acedillo Rey R.⁶,Bagga Amit⁷,Bohm Clara⁸⁹,Brown Pierre Antoine¹⁰^ORCID,Cote Brenden¹¹,Dev Varun¹²,Harris Claire¹³,Hiremath Swapnil¹⁴^ORCID,Kiaii Mercedeh¹⁵,Lacson Eduardo¹⁶,Molnar Amber O.¹⁷^ORCID,Oliver Matthew J.¹⁸,Parmar Malvinder S.¹⁹^ORCID,McRae Jennifer M.²⁰,Nathoo Bharat²¹,Quinn Kathleen²²,Shah Nikhil²³,Silver Samuel A.²⁴^ORCID,Tascona Daniel J.²⁵,Thompson Stephanie²⁶^ORCID,Ting Robert H.²⁷,Tonelli Marcello²⁸,Vorster Hans²⁹,Wadehra Davinder B.³⁰,Wald Ron³¹,Wolf Myles³²,Garg Amit X.¹^ORCID

Affiliation:

1. Division of Nephrology, Department of Medicine, Victoria Hospital, London Health Sciences Centre, ON, Canada

2. Division of Endocrinology, Department of Medicine, St. Joseph’s Hospital, London, ON, Canada

3. Department of Epidemiology and Biostatistics, Western University, London, ON, Canada

4. Lawson Health Research Institute, London Health Sciences Centre, ON, Canada

5. ICES Western, London, ON, Canada

6. Department of Medicine, Thunder Bay Regional Health Sciences Centre, ON, Canada

7. Windsor Regional Hospital, ON, Canada

8. Chronic Disease Innovation Centre, Winnipeg, MB, Canada

9. University of Manitoba, Winnipeg, Canada

10. Department of Medicine, The Ottawa Hospital Research Institute, University of Ottawa, ON, Canada

11. Patient Partner, London Health Sciences Centre, ON, Canada

12. Humber River Hospital, Toronto, ON, Canada

13. Division of Nephrology, Department of Medicine, Vancouver General Hospital, The University of British Columbia, Canada

14. Department of Medicine, University of Ottawa, ON, Canada

15. Division of Nephrology, Department of Medicine, St. Paul’s Hospital, Vancouver, BC, Canada

16. Division of Nephrology, Tufts University School of Medicine, Boston, MA, USA

17. Department of Medicine, St Joseph’s Healthcare Hamilton, ON, Canada

18. Division of Nephrology, Department of Medicine, Sunnybrook Health Sciences Centre, University of Toronto, ON, Canada

19. Department of Medicine, Timmins and District Hospital, ON, Canada

20. Division of Nephrology, Department of Medicine, University of Calgary, AB, Canada

21. Mackenzie Health, Richmond Hill, ON, Canada

22. Niagara Health System, St. Catharines, ON, Canada

23. University of Alberta, Edmonton, Canada

24. Division of Nephrology, Kingston Health Sciences Center, Queen’s University, ON, Canada

25. Orillia Soldiers’ Memorial Hospital, ON, Canada

26. Division of Nephrology, University of Alberta, Edmonton, Canada

27. University of Toronto, ON, Canada

28. Cumming School of Medicine, University of Calgary, AB, Canada

29. Can-SOLVE CKD Network, Vancouver, BC, Canada

30. William Osler Health System, Etobicoke, ON, Canada

31. Division of Nephrology, St. Michael’s Hospital, University of Toronto, ON, Canada

32. Division of Nephrology, Department of Medicine, Duke Clinical Research Institute, Duke University School of Medicine, Durham, NC, USA

Abstract

Purpose of Review: Magnesium is an essential mineral for bone metabolism, but little is known about how magnesium intake alters fracture risk. We conducted a narrative review to better understand how magnesium intake, through supplementation, diet, or altering the concentration of dialysate magnesium, affects mineral bone disease and the risk of fracture in individuals across the spectrum of kidney disease. Sources of Information: Peer-reviewed clinical trials and observational studies. Methods: We searched for relevant articles in MEDLINE and EMBASE databases. The methodologic quality of clinical trials was assessed using a modified version of the Downs and Black criteria checklist. Key Findings: The role of magnesium intake in fracture prevention is unclear in both the general population and in patients receiving maintenance dialysis. In those with normal kidney function, 2 meta-analyses showed higher bone mineral density in those with higher dietary magnesium, whereas 1 systematic review showed no effect on fracture risk. In patients receiving maintenance hemodialysis or peritoneal dialysis, a higher concentration of dialysate magnesium is associated with a lower concentration of parathyroid hormone, but little is known about other bone-related outcomes. In 2 observational studies of patients receiving hemodialysis, a higher concentration of serum magnesium was associated with a lower risk of hip fracture. Limitations: This narrative review included only articles written in English. Observed effects of magnesium intake in the general population may not be applicable to those with chronic kidney disease particularly in those receiving dialysis.

Funder

Canadian Institutes of Health Research

Academic Medical Organization of Southwestern Ontario

Publisher

SAGE Publications

Subject

Nephrology

Link

http://journals.sagepub.com/doi/pdf/10.1177/20543581231154183

Reference91 articles.