Affiliation:
1. State Key Laboratory of Characteristic Chinese Medicine Resources in Southwest China, Pharmacy College, Chengdu University of TCM, Chengdu, PR China
2. Clinical Lab, Shenzhen University General Hospital, Shenzhen, PR China
3. College of Medical Technology, Chengdu University of TCM, Chengdu, PR China
Abstract
A new phenolic glycoside, 7-(4- O- β-D-glucopyranosyl, 3-methoxyphenyl)-6,8-dihydrofuro[3′,4′:7,8]naphtho[1,2-d][1,3]dioxol-10(7H)-one, named malconenoside A (1), was isolated from Bupleurum malconense Shan et Y. Li . The structure, including absolute configurations, was assigned by using spectroscopic methods and ECD calculation. Biological activities of compound 1 towards human cancer cells (HepG2, BGC-823, and A549) were evaluated. The most sensitive two cell lines were HepG2 and BGC823, in which the IC50 values of compound 1 were 8.70 and 16.94 μM, respectively.
Funder
Scientific research promotion plan of “Xinglin Scholars”
National Natural Science Foundation of China
Application basic research project of the science and technology department of Sichuan Province
the fund of scientific research innovation team construction in Sichuan Procincial University
China Postdoctoral Science Foundation
Subject
Complementary and alternative medicine,Plant Science,Drug Discovery,Pharmacology,General Medicine
Cited by
1 articles.
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