Antiangiogenic Chromanones from Cynanchum thesiodes-Reference-Cited by-同舟云学术

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Antiangiogenic Chromanones from Cynanchum thesiodes

Published:2018-12 Issue:12 Volume:13 Page:1934578X1801301
ISSN:1934-578X
Container-title:Natural Product Communications
language:en
Short-container-title:Natural Product Communications

Author:

Wei Rongrui¹,Ma Qinge¹,Zhong Guoyue¹,Yang Ming¹,Sang Zhipei²

Affiliation:

1. State Key Laboratory of Innovative Drugs and High Efficiency Energy Saving and Consumption Reduction Pharmaceutical Equipment, Research Center of Natural Resources of Chinese Medicinal Materials and Ethnic Medicine, Key Laboratory of Modern Preparation of TCM of Ministry of Education, Jiangxi University of Traditional Chinese Medicine, Nanchang, 330004, China

2. College of Chemistry and Pharmaceutical Engineering, Nanyang Normal University, Nanyang, 473061, China

Abstract

A total of 10 chromanone derivatives (1–10), including two new compounds (1 and 2), were isolated from the fruits of Cynanchum thesiodes, and their structures were identified based on UV, IR, MS and NMR spectroscopic data, and comparison with those of reference compounds. The isolated compounds (1–10) were evaluated for their antiangiogenic activity by MTT assay using axitinib as a positive control. As a result, 1, 2, 3 and 9 exhibited important antiangiogenic activity with IC50 values of 13.8, 11.9, 43.6, and 74.8 μM, respectively.

Publisher

SAGE Publications

Subject

Complementary and alternative medicine,Plant Science,Drug Discovery,Pharmacology,General Medicine

Link

http://journals.sagepub.com/doi/pdf/10.1177/1934578X1801301221

Reference16 articles.

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