Affiliation:
1. Shizuoka Institute of Science and Technology, Fukuroi, Shizuoka, Japan
2. Faculty of Agriculture, University of the Ryukyus, Nishihara, Okinawa, Japan
3. National Institute of Technology, Hachinohe College, Hachinohe, Aomori, Japan
Abstract
A new lobane-type diterpenoid, loba-8,10,13(15)-triene-14,17,18-triol 17-acetate (1), and 5 known compounds, lobatriene (2), (17 R)-loba-8,10,13(15)-triene-17,18-diol (3), loba-8,10,13(15)-triene-14,17,18-triol 14,17-diacetate (4), loba-8,10,13(15)-triene-14,17,18-triol 14-acetate (5), and lobatrienetriol (6), were isolated from a population of Okinawan soft coral Lobophytum sp. The structures of these compounds were elucidated by spectroscopy, including nuclear magnetic resonance and high-resolution mass spectrometry. The cytotoxicity and genotoxicity of these compounds were tested using human lymphoblastoid TK6 cells.
Subject
Complementary and alternative medicine,Plant Science,Drug Discovery,Pharmacology,General Medicine