Affiliation:
1. Bioorganic Chemistry Laboratory, National Institute of Oceanography (CSIR) Goa-403004, India
2. Department of Chemistry, University of Washington, Seattle Washington-98915, USA
Abstract
Ethyl acetate extract of the sponge Ircinia sp., collected by SCUBA divers off the coast of southern India, contained a cholest-based sterol of insignificant antimicrobial activity, with one carboxylic acid side chain (3α, 7β-dihydroxy-5β-cholan-24-oic acid, DCA). The structure of the compound was determined by spectroscopic data and single crystal X-ray diffraction studies. DCA crystallizes in the tetragonal space group P41212, chirality documented by solution optical rotation [α]D = +67.4° ( c 0.16, CHCl3).
Subject
Complementary and alternative medicine,Plant Science,Drug Discovery,Pharmacology,General Medicine