Two New Cyclic Depsipeptides from the Endophytic Fungus Fusarium sp-Reference-Cited by-同舟云学术

Two New Cyclic Depsipeptides from the Endophytic Fungus Fusarium sp

Published:2015-10 Issue:10 Volume:10 Page:1934578X1501001
ISSN:1934-578X
Container-title:Natural Product Communications
language:en
Short-container-title:Natural Product Communications

Author:

Lv Fang¹²,Daletos Georgios²,Lin Wenhan³,Proksch Peter²

Affiliation:

1. School of Life Science, Beijing Institute of Technology, 100081 Beijing, People's Republic of China

2. Institute of Pharmaceutical Biology and Biotechnology, Heinrich-Heine University, Universitaetsstrasse 1, 40225 Duesseldorf Germany

3. State Key Laboratory of Natural and Biomimetic Drugs, Peking University, 100191 Beijing, People's Republic of China

Abstract

Two new cyclic depsipeptides, W493 C (1) and D (2), along with two known derivatives W493 A (3) and B (4) were obtained from the endophytic fungus Fusarium sp. isolated from the Mangrove plant Ceriops tagal. The structures of the new compounds were determined on the basis of one- and two dimensional NMR and high-resolution mass spectroscopic data. The absolute configurations of the amino acid residues of 1 and 2 were confirmed by application of Marfey's method. W493 A (3) and B (4) exhibited moderate activity against the fungus Cladosporium cladosporiodes and weak antitumor activity against the human ovarian cancer cell line A2780.

Publisher

SAGE Publications

Subject

Complementary and alternative medicine,Plant Science,Drug Discovery,Pharmacology,General Medicine

Link

http://journals.sagepub.com/doi/pdf/10.1177/1934578X1501001011

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