Affiliation:
1. Key Laboratory of Xinjiang Phytomedicine Resource and Utilization, Ministry of Education, School of Pharmacy, Shihezi University, P.R. China
2. School of Chinese Materia Resources, Guangdong Pharmaceutical University, Guangzhou, P.R. China
3. Laboratory of Medicinal Plant Biotechnology, College of Pharmacy, Zhejiang Chinese Medical University, Hangzhou, P.R. China
4. College of Life Sciences and Medicine, Zhejiang Sci-Tech University, Hangzhou, P.R. China
Abstract
A new eremophilanolide sesquiterpene, 1α,6β,10β-trihydroxyeremophila-7(11),8-dien-12,8-olide (macrophyllalarin A, 1), and along with 5 known eremophilanolide sesquiterpenes, 6α,10β-dihydroxyeremophila-7(11)-en-12,8-olide (2), 8β-hydroxyeremophila-7(11)-en-12,8α(15,6α)-diolide (3), 6α,15β-epoxy-8β-hydroxyeremophila-7(11)-en-8α,12-olide (4), 6β,10α-dihydroxy-1-oxo-eremophila-7(11),8-dien-8,12-olide (5), and 1β,10-epoxy-6β,8β-dihydroxyeremophila-7(11)-en-8α,12-olide (6), were isolated from the roots and rhizomes of Ligularia macrophylla. The structure of the new compound was identified by comprehensive spectral analysis.
Subject
Complementary and alternative medicine,Plant Science,Drug Discovery,Pharmacology,General Medicine
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