Compounds from the Roots of Codonopsis pilosula and Their SIRT1 Regulatory Activity-Reference-Cited by-同舟云学术

Compounds from the Roots of Codonopsis pilosula and Their SIRT1 Regulatory Activity

Published:2018-01 Issue:1 Volume:13 Page:1934578X1801300
ISSN:1934-578X
Container-title:Natural Product Communications
language:en
Short-container-title:Natural Product Communications

Author:

Zheng Tao¹²,Cheng Li-Zhi¹³,Yan Yong-Ming⁴,Xu Fu-Rong²,Tang Xiao-Long⁴,Li Xiao-Zhen¹²,Qin Fu-Ying¹,Liu Bao-Hua⁴,Cheng Yong-Xian¹⁴³

Affiliation:

1. State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, People's Republic of China

2. Yunnan University of Traditional Chinese Medicine, Kunming 650504, People's Republic of China

3. Henan University of Traditional Chinese Medicine, Zhengzhou 450008, People's Republic of China

4. School of Pharmaceutical Sciences, Health Science Center, Shenzhen University, Shenzhen 518060, People's Republic of China

Abstract

Two new compounds, pilosuloside A (1) and pilosulain A (2), one new natural occurring compound (3), and twelve known compounds (4-15), were isolated from the roots of Codonopsis pilosula. Their structures were elucidated by a combination of spectroscopic methods. Regulation of SIRT1 activity by all the compounds was evaluated. The results showed that 4 could activate SIRT1 in a concentration-dependent manner.

Publisher

SAGE Publications

Subject

Complementary and alternative medicine,Plant Science,Drug Discovery,Pharmacology,General Medicine

Link

http://journals.sagepub.com/doi/pdf/10.1177/1934578X1801300112

Reference28 articles.

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2. C14-Polyacetylene glucosides fromCodonopsis pilosula

3. Sesquiterpene glycosides from the roots of Codonopsis pilosula

4. Phenolic Glycosides and Pyrrolidine Alkaloids from Codonopsis tangshen

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