In Vitro Antiviral Activity of Heterophyllaea pustulata Extracts-Reference-Cited by-同舟云学术

In Vitro Antiviral Activity of Heterophyllaea pustulata Extracts

Published:2012-08 Issue:8 Volume:7 Page:1934578X1200700
ISSN:1934-578X
Container-title:Natural Product Communications
language:en
Short-container-title:Natural Product Communications

Author:

Konigheim Brenda S.¹²,Beranek Mauricio²,Comini Laura R.¹,Aguilar Javier J.²,Marioni Juliana¹,Cabrera José L.¹,Contigiani Marta S.²,Montoya Susana C. Núñez¹

Affiliation:

1. Department of Pharmacy, School of Chemistry, National University of Córdoba, IMBIV-CONICET. Edificio Ciencias II, Ciudad Universitaria, 5016 Córdoba, Argentina

2. National University of Córdoba, Ciudad Universitaria, 5016 Córdoba, Argentina

Abstract

The antiviral activity was tested of different polarity extracts, with differing chemical composition, obtained from aerial parts of Heterophyllaea pustulata Hook f. (Rubiaceae) against Herpes Simplex Virus Type I (HSV-1) and Saint Louis Encephalitis Virus (SLEV). The Vero cell line was employed as a host cell for the antiviral assessment of benzene (Ben), ethyl acetate (EtOAc) and ethanol (EtOH) extracts by means of the Neutral Red uptake assay and plaque reduction test. None of the extracts showed antiviral activity against SLEV. Only the extracts (Ben and EtOAc) with a high content of anthraquinones (AQs) inhibited HSV-1 replication, exhibiting Selectivity Index (SI) values of 2.7 and 2.4, respectively. Therefore, these extracts could be good candidates as natural sources for antiviral drug development against HSV-1.

Publisher

SAGE Publications

Subject

Complementary and alternative medicine,Plant Science,Drug Discovery,Pharmacology,General Medicine

Link

http://journals.sagepub.com/doi/pdf/10.1177/1934578X1200700816

Reference27 articles.

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2. Anthraquinone Derivatives from Heterophyllaea pustulata

3. Antifungal anthraquinones from Morinda lucida

4. Antiviral, Cyototoxic And Antimicrobial Activities Of Anthraquinones Isolated From The Roots Of Morinda Elliptica

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