Inhibition of Helicobacter pylori and Gastric Cancer Cells by Lipid Aldehydes from Viburnum opulus (Adoxaceae)-Reference-Cited by-同舟云学术

Inhibition of Helicobacter pylori and Gastric Cancer Cells by Lipid Aldehydes from Viburnum opulus (Adoxaceae)

Published:2007-10 Issue:10 Volume:2 Page:1934578X0700201
ISSN:1934-578X
Container-title:Natural Product Communications
language:en
Short-container-title:Natural Product Communications

Author:

Laux Maria Teresa¹,Aregullin Manuel²,Rodriguez Eloy³

Affiliation:

1. College of Veterinary Medicine, Department of Molecular Medicine, Cornell University, Ithaca, NY 14853, USA

2. College of Agriculture and Life Science, Department of Molecular Biology & Genetics, Ithaca, NY 14853, USA

3. Department of Plant Biology, Cornell University, Ithaca, NY 14853, USA

Abstract

A unique group of bioactive, naturally occurring lipid aldehydes were isolated from the fruits of Viburnum opulus, (family Adoxaceae). The natural occurrences of these fatty acid derived aldehydes are reported here for the first time. Helicobacter pylori is a prevalent gastroduodenal pathogen, a causal agent of chronic gastritis and peptic ulcers and an important co-factor in gastric cancer development. We investigated the chemistry and bioactivity of these active constituents by evaluating their ability to inhibit the growth of H. pylori and to induce apoptosis in a gastric cancer cell line (CRL-5971) in vitro.

Publisher

SAGE Publications

Subject

Complementary and alternative medicine,Plant Science,Drug Discovery,Pharmacology,General Medicine

Link

http://journals.sagepub.com/doi/pdf/10.1177/1934578X0700201009

Reference9 articles.

1. MoermanDE. (1986) Medicinal plants of native America. University of Michigan Museum of Anthropology. Technical Reports, Number 19. Research Reports in Ethnobotany, Contribution 2. Ann Arbor, Michigan 1: 512

2. BartrumD, GiffordJLT. (1958) Hydrangeas and Viburnums, London, 117–159.

3. In VitroInhibitory Effect of Flavonoids on Growth, Infection and Vacuolation ofHelicobacter pylori

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