Efficient Production of the Potent Antimicrobial Metabolite “Terrein” From the Fungus Aspergillus terreus

Abstract

The endophytic fungus Aspergillus terreus (JAS-2) derived from Achyranthes aspera possesses multiple bioactive metabolites, one of which is terrein, a potent antimicrobial substance. Here we report the improved biosynthesis of terrein in cultures grown in media with a fixed carbon and modified nitrogen source (4% dextrose, 1% casein) for 15 days, after which pure crystals of terrein were obtained in the culture medium. We suggest that our improved method is effective for improving the quantity and quality of terrein produced. Terrein has shown potent antimicrobial activities against various microbes that may lead to its further use to combat antimicrobial resistance which threatens the community worldwide.