Bioactive Isocoumarins from a Terrestrial Streptomyces sp. ANK302-Reference-Cited by-同舟云学术

Bioactive Isocoumarins from a Terrestrial Streptomyces sp. ANK302

Published:2011-01 Issue:1 Volume:6 Page:1934578X1100600
ISSN:1934-578X
Container-title:Natural Product Communications
language:en
Short-container-title:Natural Product Communications

Author:

Zinad Dhafer Saber¹,Shaaban Khaled A.¹,Abdalla Muna Ali¹,Islam Md. Tofazzal²³,Schüffler Anja⁴,Laatsch Hartmut¹

Affiliation:

1. Institute of Organic and Biomolecular Chemistry, University of Göttingen, Tammannstrasse 2, D-37077 Göttingen, Germany

2. Department of Crop Sciences, Plant Pathology and Plant Protection, Georg-August Universität Göttingen, Grisebachstraβe 6, 3707 Göttingen, Germany

3. Current address: Department of Biotechnology, Bangabandhu Sheikh Mujibur Rahman Agricultural University, Gazipur-1706, Bangladesh

4. Institute of Biotechnology and Drug Research, D-67663 Kaiserslautern, Germany

Abstract

Four isocoumarins have been isolated from the terrestrial Streptomyces sp. ANK302, namely 6,8-dimethoxy-3-methylisocoumarin (1), 6,8-dihydroxy-3-methylisocoumarin (2), 6,8-dihydroxy-7-methoxy-3-methylisocoumarin (3), and 6,7,8-trimethoxy-3-methylisocoumarin (4). Compound 1 is a new naturally-occurring isocoumarin, and 2 was isolated as a new bacterial product. The structures 1-4 were deduced from high resolution mass, 1D and 2D NMR spectra and by comparison with related compounds from the literature. Compound 2 showed a strong zoosporicidal activity at a concentration of 5 μg/mL against a phytopathogenic oomycete, Plasmopara viticola, and 1 was active against Candida albicans.

Publisher

SAGE Publications

Subject

Complementary and alternative medicine,Plant Science,Drug Discovery,Pharmacology,General Medicine

Link

http://journals.sagepub.com/doi/pdf/10.1177/1934578X1100600111

Reference12 articles.

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2. Cercophorins A−C: Novel Antifungal and Cytotoxic Metabolites from the Coprophilous Fungus Cercophora areolata

3. Polygonolide, an isocoumarin from Polygonum hydropiper possessing anti-inflammatory activity

4. 531. Some synthetical investigations in isocoumarin chemistry

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