Chemoreversal Metabolites from the Endophytic Fungus Penicillium citrinum Isolated from a Mangrove Avicennia marina-Reference-Cited by-同舟云学术

Chemoreversal Metabolites from the Endophytic Fungus Penicillium citrinum Isolated from a Mangrove Avicennia marina

Published:2015-07 Issue:7 Volume:10 Page:1934578X1501000
ISSN:1934-578X
Container-title:Natural Product Communications
language:en
Short-container-title:Natural Product Communications

Author:

Liu Jin¹²,Xu Meng³,Zhu Ming-Yi⁴,Feng Yun⁵

Affiliation:

1. The First Clinical Medical College of Jinan Universtiy, Guangzhou 510632, P.R. China

2. Department of Otolaryngology, The Affiliated Hospital of Youjiang Medical University for Nationalities, Baise 533000, P.R. China

3. Department of Oncology, The First Affiliated Hospital, Jinan University, Guangzhou 510632, P.R. China

4. Medical Research Center, Youjiang Medical University for Nationalities, Baise 533000, P.R. China

5. Department of Neurology, The Affiliated Hospital of Youjiang Medical University for Nationalities, Baise 533000, P.R. China

Abstract

Two new compounds, named ( Z)-7,4′-dimethoxy-6-hydroxyaurone-4- O-β-glucopyranoside (1) and (-)-4- O-(4- O-β-D-glucopyranosylcaffeoyl)quinic acid (2), were isolated from the endophytic fungus Penicillium citrinum of Avicennia marina. Their structures were elucidated on the basis of spectroscopic analysis. Additionally, compound 2 exhibited potent chemoreversal activity, mainly by inhibiting P-glycoprotein efflux pump function.

Publisher

SAGE Publications

Subject

Complementary and alternative medicine,Plant Science,Drug Discovery,Pharmacology,General Medicine

Link

http://journals.sagepub.com/doi/pdf/10.1177/1934578X1501000717

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