Synthesis, Cytotoxic and Contraceptive Activity of 6,8,9-Trihydroxy-2-methyl-2H-naphtho[2,3-b]pyran-5,10-dione, a Pigment of Echinothrix diadema, and its Analogs-Reference-Cited by-同舟云学术

Synthesis, Cytotoxic and Contraceptive Activity of 6,8,9-Trihydroxy-2-methyl-2H-naphtho[2,3-b]pyran-5,10-dione, a Pigment of Echinothrix diadema, and its Analogs

Published:2015-07 Issue:7 Volume:10 Page:1934578X1501000
ISSN:1934-578X
Container-title:Natural Product Communications
language:en
Short-container-title:Natural Product Communications

Author:

Pokhilo Natalia D.¹,Melman Galina I.¹,Kiseleva Marina I.¹,Denisenko Vladimir A.¹,Anufriev Victor Ph.¹

Affiliation:

1. G. B. Elyakov Pacific Institute of Bioorganic Chemistry, Far East Branch of the Russian Academy of Sciences, 690022, Vladivostok, Prospect 100 let Vladivostoku, 159, Russia

Abstract

6,8,9-Trihydroxy-2-methyl-2 H-naphtho[2,3- b]pyran-5,10-dion, a pigment of the sea urchin Echinothrix diadema, and six analogs were synthesized. The cytotoxic activity and contraceptive properties of the synthesized pyranonaphthazarins have been investigated using the sperm and eggs of the sea urchin Strongylocentrotus intermedius.

Publisher

SAGE Publications

Subject

Complementary and alternative medicine,Plant Science,Drug Discovery,Pharmacology,General Medicine

Link

http://journals.sagepub.com/doi/pdf/10.1177/1934578X1501000727

Reference37 articles.

1. Isolation of Eleven New Spinochromes from Echinoids of the Genus Echinothrix

2. Extraction and antioxidant property of polyhydroxylated naphthoquinone pigments from spines of purple sea urchin Strongylocentrotus nudus

3. Echinamines A and B, First Aminated Hydroxynaphthazarins from the Sea Urchin Scaphechinus mirabilis

4. Synthesis of some hydroxynaphthazarins and their cardioprotective effects under ischemia-reperfusion in vivo

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