Chemical Constituents and LC-profile of Fresh Formosan Lonicera Japonica Flower Buds

Author:

Lo I-Wen1,Cheng Yuan-Bin12,Hsieh Yi-Jin1,Hwang Tsong-Long3,Shieh Deng-En4,Chang Fang-Rong1567,Wu Yang-Chang18910

Affiliation:

1. Graduate Institute of Natural Products, College of Pharmacy, Kaohsiung Medical University, Kaohsiung 80708, Taiwan

2. Center for Infectious Disease and Cancer Research, Kaohsiung Medical University, Kaohsiung 80708, Taiwan

3. Graduate Institute of Natural Products, College of Medicine, Chang Gung University, Taoyuan 33302, Taiwan

4. Department of Food Science and Technology, Ta-Jen University, Pingtung 90741, Taiwan

5. Cancer Center, Kaohsiung Medical University Hospital, Kaohsiung 80708, Taiwan

6. Department of Marine Biotechnology and Resources, National Sun Yat-Sen University, Kaohsiung 80424, Taiwan

7. Research Center for Natural Product & Drug Development, Kaohsiung Medical University, Kaohsiung 80708, Taiwan

8. School of Pharmacy, College of Pharmacy, China Medical University, Taichung 40402, Taiwan

9. Chinese Medicine Research and Development Center, China Medical University Hospital, Taichung 40402, Taiwan

10. Center for Molecular Medicine, China Medical University Hospital, Taichung 40402, Taiwan

Abstract

One new secoiridoid glucoside, ethylsecologanin dimethyl acetal (1), along with 15 known compounds, comprising six iridoid glucosides (2–7), six flavonoids (8–13), two sterol glucosides (14 and 15), and chlorogenic acid (16) were isolated from the flower buds of Formosan Lonicera japonica. The structures of these isolates were determined on the basis of mass and spectroscopic analyzes. In addition, the chemical profiles of fresh Formosan honeysuckle buds and the dried Chinese one were compared by HPLC with a PDA detector. The calibration curve of the active component, chlorogenic acid, was also provided. As a result of the constituent similarity, Formosan L. japonica can be an alternative to the Chinese honeysuckles.

Publisher

SAGE Publications

Subject

Complementary and alternative medicine,Plant Science,Drug Discovery,Pharmacology,General Medicine

Reference25 articles.

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2. XuBS. (1988) Flora Reipublicae Popularis Sinicae, Vol. 72, Science Press, Beijing China. 236–238.

3. ScheidV, BenskyD, BaroletR. (2009) Chinese Herbal Medicine Formulas and Strategies, 2nd ed. Eastland Press, Seattle, Washington USA. 44–45.

4. Saponins and Volatile Constituents from Lonicera japonica Growing in the Western Himalayan Region of India

5. Allergy-Preventive Effects of Chlorogenic Acid and Iridoid Derivatives from Flower Buds of Lonicera japonica

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