Stereochemistry and NMR Data Assignment of Cyclopeptide Alkaloids from Zizyphus Oxyphylla

Author:

Nisar Muhammad1,Kaleem Waqar Ahmad2,Adhikari Achyut3,Ali Zulfiqar3,Hussain Nusrat3,Khan Inamullah2,Qayum Mughal2,Choudhary M. Iqbal3

Affiliation:

1. Institute of Chemical Sciences, University of Peshwar, Peshwar-25120, Pakistan

2. Department of Pharmacy, University of Peshwar, Peshwar -25120, Pakistan

3. International Center for Chemical and Biological Sciences, H. E. J. Research Institute of Chemistry, University of Karachi, Karachi-75270, Pakistan

Abstract

The structures of (3 S,7 R,13 S)-6-[2-(dimethylamino)-3-phenylpropanoyl]-19-methoxy-2-oxa-6,9,15-triazatetracyclo[16.3.1.03,7. 09,13]docosa-1-(22),16,18,20-tetraene-8,14-dione (1), nummularin-C (2) and nummularin-R (3) have been previously determined mainly based on mass spectrometric data. Stereochemistry and complete 1H and 13C NMR spectroscopic data assignments of these compounds are now described. Compounds 1 and 2 are reported for the first time from

Publisher

SAGE Publications

Subject

Complementary and alternative medicine,Plant Science,Drug Discovery,Pharmacology,General Medicine

Reference14 articles.

1. QaiserM, NazimudinS. (1981) Flora of Pakistan. No.140, NasirE, AliSI (Eds). Department of Botany, University of Karachi, Karachi, Pakistan. 9–17;

2. KirtikarKR, BasuBD. (1984) Indian Medicinal Plants. Vol. I, Lalit Mohan Basu, Allahabad, India. 593;

3. HanBH, ParkMH. (1986) Folk Medicine: The Art and Science. The American Chemical Society, Washington, DC, 205.

4. Antinociceptive activity of Zizyphus spina-christi root bark extract

5. Antinociceptive and antipyretic activities of theZizyphus oxyphylla Edgew. leaves

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