Polar Alkaloids from the Caribbean Marine Sponge Niphates Digitalis-Reference-Cited by-同舟云学术

Polar Alkaloids from the Caribbean Marine Sponge Niphates Digitalis

Published:2010-08 Issue:8 Volume:5 Page:1934578X1000500
ISSN:1934-578X
Container-title:Natural Product Communications
language:en
Short-container-title:Natural Product Communications

Author:

Regalado Erik L.¹,Mendiola Judith²,Laguna Abilio¹,Nogueiras Clara³,Thomas Olivier P.⁴

Affiliation:

1. Department of Chemistry, Center of Marine Bioproducts (CEBIMAR), Loma y 37, Alturas del Vedado, C.P. 10400 Havana, Cuba

2. Department of Parasitology, Institute of Tropical Medicine “Pedro Kourí” (IPK), Autopista Novia del Mediodía km 6 ½, PO Box 601, Marianao 13, Havana, Cuba

3. Center of Natural Products (CPN), Faculty of Chemistry, University of Havana, San Lázaro y L, Plaza, C.P. 10400 Havana, Cuba

4. Université de Nice-Sophia Antipolis, Laboratoire de Chimie des Molécules Bioactives et des Arômes (LCMBA), UMR 6001 CNRS, Institut de Chimie de Nice, Faculté des Science, Parc Valrose, 06108 Nice Cedex 02, France

Abstract

A method involving flash chromatography, semi-preparative phenylhexyl RP HPLC-DAD-ELSD combined with analytic polar-RP HPLC-DAD, was applied to separate and purify six highly nitrogenated bases and a bicyclic amidine alkaloid, the major components of the marine sponge Niphates digitalis. Their structures were identified as 1,8-diazabicyclo[5.4.0]undec-7-ene (1), deoxycytidine (2), phenylalanine (3), adenosine (4), deoxyguanosine (5), adenine (6) and thymidine (7) on the basis of spectroscopic data analyses. This is the first report of these compounds in a marine sponge belonging to the Niphates genus and the first evidence of the presence of 1 from a natural source.

Publisher

SAGE Publications

Subject

Complementary and alternative medicine,Plant Science,Drug Discovery,Pharmacology,General Medicine

Link

http://journals.sagepub.com/doi/pdf/10.1177/1934578X1000500807

Reference33 articles.

1. Manzamine B and E and Ircinal A Related Alkaloids from an Indonesian Acanthostrongylophora Sponge and Their Activity against Infectious, Tropical Parasitic, and Alzheimer's Diseases

2. Anticancer Activity Evaluation of Kuanoniamines A and C Isolated from the Marine Sponge Oceanapia sagittaria, Collected from the Gulf of Thailand

3. Bioactive Metabolites from the Caribbean Sponge Aka coralliphagum

4. Pyrinadine A, a novel pyridine alkaloid with an azoxy moiety from sponge Cribrochalina sp.

5. Niphatynes, methoxylamine pyridines from the marine sponge, niphates SP.

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