Analytic Reviews: Cardiac Surgery as a Cause of Acute Kidney Injury: Pathogenesis and Potential Therapies

Author:

Rosner Mitchell H.1,Portilla Didier2,Okusa Mark D.3

Affiliation:

1. Department of Internal Medicine, University of Virginia Health System, Charlottesville, Virginia,

2. Division of Nephrology, Department of Medicine, University of Arkansas for Medical Sciences, Little Rock, Arkansas

3. Department of Internal Medicine, University of Virginia Health System, Charlottesville, Virginia

Abstract

Cardiopulmonary bypass surgery occurs in nearly 1 million patients per year. Acute kidney injury requiring dialysis can occur in up to 1% of these patients. The development of acute kidney injury is associated with substantial morbidity and mortality independent of all other factors, and many patients are left dependent on dialysis therapies. The pathogenesis of acute kidney injury involves multiple pathways. Hemodynamic, inflammatory, and nephrotoxic factors are involved and overlap each other in leading to kidney injury. Clinical studies have identified risk factors for acute kidney injury that can be used to effectively determine the risk of acute kidney injury in patients undergoing bypass surgery. These high-risk patients can then be targeted for renal protective strategies. Thus far, no single strategy has conclusively demonstrated its ability to prevent renal injury post-bypass surgery. Novel anti-inflammatory agents are in development and offer hope as potential therapies.

Publisher

SAGE Publications

Subject

Critical Care and Intensive Care Medicine

Reference160 articles.

1. Lillehei CW Historical development of cardiopulmonary bypass in Minnesota. In: Gravlee GP, Davis RF , Kurusz M, Utley JR, eds. Cardiopulmonary Bypass: Principles and Practice . 2nd ed. Philadelphia: Lippincott, Williams & Wilkins; 2000:3-21.

2. Renal Dysfunction after Myocardial Revascularization: Risk Factors, Adverse Outcomes, and Hospital Resource Utilization

3. Etiology, incidence, and prognosis of renal failure following cardiac operations

4. Acute renal failure following cardiac operations

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3