The Use of Sodium Bicarbonate in the Treatment of Tricyclic Antidepressant-Induced Arrhythmias-Reference-Cited by-同舟云学术

The Use of Sodium Bicarbonate in the Treatment of Tricyclic Antidepressant-Induced Arrhythmias

Published:1973-02 Issue:3 Volume:1 Page:203-210
ISSN:0310-057X
Container-title:Anaesthesia and Intensive Care
language:en
Short-container-title:Anaesth Intensive Care

Author:

Brown T. C. K.¹,Barker G. A.¹,Dunlop M. E.¹,Loughnan P. M.¹

Affiliation:

1. Departments of Anaesthesia and Intensive Care, Royal Children's Hospital, Melbourne

Abstract

Sodium bicarbonate has been successfully used clinically to treat arrhythmias induced by tricyclic antidepressant drugs (imipramine, amitriptyline, nortriptyline, dibenzepin). Experiments conducted on puppies showed that arrhythmias caused by amitriptyline disappear when acidosis is adequately treated. Plasma protein binding of amitriptyline increases as pH rises, reducing the unbound fraction of drug. This mechanism is an important factor in the antiarrhythmic action of sodium bicarbonate in tricyclic antidepressant overdosage.

Publisher

SAGE Publications

Subject

Anesthesiology and Pain Medicine,Critical Care and Intensive Care Medicine

Link

http://journals.sagepub.com/doi/pdf/10.1177/0310057X7300100302

Reference13 articles.

1. Relationship Between the Plasma Level of Diphenylhydantoin Sodium and Its Cardiac Antiarrhythmic Effects

2. Plasma protein binding of tricyclic anti-depressants in man

3. Tachyarrhythmia in Severe Imipramine Overdose Controlled by Practolol

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