Pregnancy in women with cystic fibrosis and diabetes: An audit of outcomes at two tertiary obstetric hospitals in Australia in the pre-cystic fibrosis transmembrane conductance regulator modulator era

Author:

Davidson Sarah J12ORCID,France Megan3,Callaway Leonie K14,Lust Karin14,Chambers Daniel45,Hopkins Peter45,Bell Scott C346,Burr Lucy478,Keating Rebecca7,Barrett Helen L89ORCID

Affiliation:

1. Women's & Newborn Services, Royal Brisbane & Women's Hospital, Herston, Australia

2. Duke University School of Medicine, Durham, NC, USA

3. Thoracic Medicine, The Prince Charles Hospital, Chermside, Australia

4. Faculty of Medicine, The University of Queensland, Herston, Australia

5. Queensland Lung Transplant Program, The Prince Charles Hospital, Chermside, Australia

6. Translational Research Institute, Woolloongabba, Australia

7. Department of Respiratory Medicine, Mater Health Services, South Brisbane, Australia

8. Mater Research Institute – The University of Queensland, South Brisbane, Australia

9. Departments of Endocrinology and Obstetric Medicine, Mater Health Services, South Brisbane, Australia

Abstract

Background Pregnancy in women with cystic fibrosis (CF) is becoming more common. Long-term metabolic issues such as diabetes are also becoming more common and have potentially important impacts on pregnancy outcomes. This study aimed to assess the impact of diabetes on pregnancy outcomes for women with CF. Methods We undertook a retrospective chart audit of pregnancies to women with CF at the two tertiary obstetric hospitals in Southeast Queensland associated with CF and transplant management clinics between 2006 and 2016. Results A total of 38 pregnancies among 26 women were identified. Four women (five pregnancies) had cystic fibrosis-related diabetes (CFRD) diagnosed prior to pregnancy, and 12 women (15 pregnancies) developed gestational diabetes (GDM) complicating pregnancy. CFRD and GDM were associated with higher rates of delivery complications, prematurity, and the need for neonatal intensive care unit admission. Conclusion Diabetes is common during pregnancy in women with CF and impacts pregnancy outcomes.

Publisher

SAGE Publications

Subject

Obstetrics and Gynecology

Reference17 articles.

1. Ahern S, Ruseckaite R, Salimi F, et al. The Australian cystic fibrosis data registry annual report, 2019. Report no. 21, Monash University, Department of Epidemiology and Preventative Medicine, January 2021.

2. Real-World Outcomes Among Patients with Cystic Fibrosis Treated with Ivacaftor: 2012–2016 Experience

3. Disease progression in patients with cystic fibrosis treated with ivacaftor: Data from national US and UK registries

4. Cystic Fibrosis Foundation Patient Registry. 2019 Annual data report. Bethesda, Maryland: Cystic Fibrosis Foundation, 2020.

5. Pregnancy in Cystic Fibrosis of the Pancreas

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