Minocycline-Induced Lupus

Abstract

OBJECTIVE: To report a case of drug-induced lupus occurring 5 months after the initiation of minocycline therapy for acne. DATA SOURCE: Case report information was obtained from the physician, patient's family, and the medical record. MEDLINE and Index Medicus were searched to obtain relevant published literature from 1966 to 1996. CASE SUMMARY: A 14-year-old white girl developed symptoms of myalgias, arthralgias, polyarthritis, and flushed face. The antinuclear antibody test was positive. Minocycline was discontinued and the patient's condition dramatically improved within 7 days. CONCLUSIONS: Healthcare providers should recognize early common and unusual symptoms of minocycline-induced lupus in adolescents being treated for acne.