Affiliation:
1. Department of Molecular Cell Biology, Institute for Cancer
Research, Oslo University Hospital, Montebello, Oslo, Norway
Abstract
As part of a starvation response, lysosomes cluster perinuclearly. This facilitates fusion between lysosomes and autophagosomes and ensures activation of catabolic processes. When nutrients are abundant, lysosomes rather translocate to the cell periphery where they contribute to anabolic signaling. The mechanisms underlying nutrient-dependent lysosome positioning have been enigmatic. Now, several recent reports shed light on these mechanisms, and we are beginning to understand how the nutritional status can control and coordinate lysosome translocation pathways. Interestingly, several of the mechanisms that control lysosome positioning depend on membrane contact sites.
Subject
General Materials Science
Cited by
4 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献