How Nutrients Orchestrate Lysosome Positioning

Author:

Raiborg Camilla1ORCID

Affiliation:

1. Department of Molecular Cell Biology, Institute for Cancer Research, Oslo University Hospital, Montebello, Oslo, Norway

Abstract

As part of a starvation response, lysosomes cluster perinuclearly. This facilitates fusion between lysosomes and autophagosomes and ensures activation of catabolic processes. When nutrients are abundant, lysosomes rather translocate to the cell periphery where they contribute to anabolic signaling. The mechanisms underlying nutrient-dependent lysosome positioning have been enigmatic. Now, several recent reports shed light on these mechanisms, and we are beginning to understand how the nutritional status can control and coordinate lysosome translocation pathways. Interestingly, several of the mechanisms that control lysosome positioning depend on membrane contact sites.

Publisher

SAGE Publications

Subject

General Materials Science

Cited by 4 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. ER as master regulator of membrane trafficking and organelle function;Journal of Cell Biology;2022-09-15

2. Bidirectional lysosome transport: a balancing act between ARL8 effectors;Nature Communications;2022-09-07

3. Faraway, so close! Functions of Endoplasmic reticulum–Endosome contacts;Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids;2020-01

4. Lysosomes as dynamic regulators of cell and organismal homeostasis;Nature Reviews Molecular Cell Biology;2019-11-25

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3