The Expression and Clinicopathological Significance of BRAF V600E and Mucin 6 in Intrahepatic Cholangiocarcinoma: A Retrospective Study

Author:

Wu Shurui1,Wang Meihong2,Zhou Qinghai3,Tang Haowen4,Wang Zhanbo5ORCID

Affiliation:

1. Medical School of Chinese PLA, Chinese PLA General Hospital, Beijing, China

2. Department of Pathology, The Hospital of PLA 80th Group Army, Shandong, China

3. Department of Hepatobiliary Surgery, Qianjiang River Hospital for Nationalities, Chongqing, China

4. Department of Hepatobiliary Surgery, Chinese PLA General Hospital, Beijing, China

5. Department of Pathology, Chinese PLA General Hospital, Beijing, China

Abstract

Aim. The study aims to explore the expression levels and clinicopathological significance of BRAF V600E and mucin 6 in intrahepatic cholangiocarcinoma. Method. Immunohistochemistry for BRAF V600E and mucin 6 was performed in 110 patients with intrahepatic cholangiocarcinoma. Subsequently, a comprehensive review of medical records and clinicopathological analysis was undertaken. Results. BRAF V600E expression was detected in 11 patients (10%); mucin 6 expression was observed in 19 intrahepatic cholangiocarcinoma specimens (17%). Thereafter, Cox regression models indicated that positive expression of either MUC6 positive (hazard ratio = 0.091, 95% confidence interval = 0.034-0.247, P < .001) and BRAF V600E positive (hazard ratio =0.150, 95% confidence interval = 0.058-0.388, P < .001) was significantly linked with longer overall survival for intrahepatic cholangiocarcinoma patients. Conclusion. The study concludes that positive expression of BRAF V600E and mucin 6 could potentially implied significant survival benefits for patients diagnosed with intrahepatic cholangiocarcinoma.

Publisher

SAGE Publications

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