Small Cell Tumors of the Thyroid Gland

Author:

Eloy Catarina1,Cameselle-Teijeiro José Manuel2,Rousseau Emmanuel3,Sobrinho-Simões Manuel145

Affiliation:

1. IPATIMUP (Institute of Molecular Pathology and Immunology of the University of Porto), Porto, Portugal

2. Clinical University Hospital & University of Santiago de Compostela, Santiago de Compostela, Spain

3. Centre Hospitalier de Mouscron, Mouscron, Belgium

4. Hospital de São João, Porto, Portugal

5. Medical Faculty of the University of Porto, Porto, Portugal

Abstract

The small cell group of thyroid tumors that includes lymphoma, poorly differentiated carcinoma, medullary carcinoma, secondary neoplasms, as well as tumors with uncertain histogenesis, remains as a valid diagnostic cul-de-sac due to its heterogeneous constitution. The existence of small cell thyroid tumors with EWSR1-FLI1 rearrangement together with neuroendocrine and/or carcinomatous differentiation raises not only differential diagnostic problems but also a very interesting therapeutic dilemma. This review explores the classification of small cell tumors of the thyroid taking into account the immunophenotype and molecular profile of such tumors.

Publisher

SAGE Publications

Subject

Pathology and Forensic Medicine,Surgery,Anatomy

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