Affiliation:
1. Department of Cardiovascular Surgery, Charité, Humboldt University, Berlin - Germany
2. The Biofluidmechanics Lab, Humboldt University, Berlin - Germany
3. Auto-Tissue Ltd., Berlin - Germany
Abstract
Background: Hydrodynamic performance of a decellularized pulmonary porcine valve was evaluated with a computer versatile pulse duplicator and compared to glutaraldehyde fixated stentless porcine bioprosthesis and a polyurethane heart valve. Methods: Decellularized pulmonary porcine matrices (Group I, n=5) were treated chemically to become cell-free collagen matrices. The findings of this heart valve were compared with aortic glutaraldehyde treated porcine prostheses (Group II, n=5) and polyurethane three leaflet valve prostheses (Group III, n=1). Measurements were performed in 0.9% saline test fluid at room temperature. Measurements compared were closing time, closing volume, systemic pressure difference and energy losses. Each valve was measured 6 times with 70 beats/minute, a stroke volume of 70 ml corresponds to a cardiac output of 4.9 L/minute. Results: Group I and group III showed no significant differences between parameters. The measured closing time was significantly different (p<0.001) between group I and II, respectively 24.333 and 53.600 ms and group II and III respectively 53.600 and 24.000. Difference in closing volume was significant (p<0.05) between groups II and I respectively 3.67 and 0.68 ms and group II and III respectively 3.67 and 0.71. Systolic mean pressure gradient was 18.25 ± 1.04 mm Hg in group II which was significantly different (p<0.001) from groups I and III, respectively 10.65 ± 0.29 mm Hg and 7.70 ± 0.30 mm Hg. Conclusions: Decellularized pulmonary porcine valves showed the same excellent performance as polyurethane valve prosthesis, which are superior to the investigated glutaraldehyde fixed xenograft.
Subject
Biomedical Engineering,Biomaterials,General Medicine,Medicine (miscellaneous),Bioengineering
Cited by
11 articles.
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