Radiological differentiation of optic neuritis with myelin oligodendrocyte glycoprotein antibodies, aquaporin-4 antibodies, and multiple sclerosis-Reference-Cited by-同舟云学术

Radiological differentiation of optic neuritis with myelin oligodendrocyte glycoprotein antibodies, aquaporin-4 antibodies, and multiple sclerosis

Published:2015-07-10 Issue:4 Volume:22 Page:470-482
ISSN:1352-4585
Container-title:Multiple Sclerosis Journal
language:en
Short-container-title:Mult Scler

Author:

Ramanathan Sudarshini¹,Prelog Kristina²,Barnes Elizabeth H³,Tantsis Esther M⁴,Reddel Stephen W⁵,Henderson Andrew PD⁶,Vucic Steve⁷,Gorman Mark P⁸,Benson Leslie A⁸,Alper Gulay⁹,Riney Catherine J¹⁰,Barnett Michael¹¹,Parratt John DE¹²,Hardy Todd A¹³,Leventer Richard J¹⁴,Merheb Vera⁴,Nosadini Margherita⁴,Fung Victor SC¹⁵,Brilot Fabienne⁴,Dale Russell C⁴

Affiliation:

1. Neuroimmunology group, Institute for Neuroscience and Muscle Research, The Kids Research Institute at the Children’s Hospital at Westmead, Sydney Medical School, University of Sydney, Sydney, Australia/Department of Neurology, Westmead Hospital, and Sydney Medical School, University of Sydney, Sydney, Australia

2. Department of Medical Imaging, the Children’s Hospital at Westmead, Sydney, Australia

3. NHMRC Clinical Trials Centre, University of Sydney, Sydney, Australia

4. Neuroimmunology group, Institute for Neuroscience and Muscle Research, The Kids Research Institute at the Children’s Hospital at Westmead, Sydney Medical School, University of Sydney, Sydney, Australia

5. Department of Neurology, Concord Repatriation General Hospital, Sydney, Australia/Brain and Mind Research Institute, University of Sydney, Sydney, Australia

6. Department of Neurology, Westmead Hospital, and Sydney Medical School, University of Sydney, Sydney, Australia/Department of Ophthalmology, Westmead Hospital, Sydney, Australia

7. Department of Neurology, Westmead Hospital, and Sydney Medical School, University of Sydney, Sydney, Australia/Western Clinical School, University of Sydney, Sydney, Australia

8. Boston Children’s Hospital, Boston, United States of America

9. Children’s Hospital of Pittsburgh, Department of Pediatrics, University of Pittsburgh, School of Medicine, Pittsburgh, United States of America

10. Neurosciences Unit, Lady Cilento Children’s Hospital, Brisbane, Australia; School of Medicine, University of Queensland, Brisbane, Australia

11. Brain and Mind Research Institute, University of Sydney, Sydney, Australia/Department of Neurology, Royal Prince Alfred Hospital, Sydney, Australia

12. Department of Neurology, Royal North Shore Hospital, Central Clinical School, University of Sydney, Sydney, Australia

13. Brain and Mind Research Institute, University of Sydney, Sydney, Australia/Department of Neurology, Concord Repatriation General Hospital, Sydney, Australia

14. Department of Neurology, University of Melbourne Department of Paediatrics, Murdoch Children’s Research Institute, The Royal Children’s Hospital, Melbourne, Australia

15. Department of Neurology, Westmead Hospital, and Sydney Medical School, University of Sydney, Sydney, Australia

Abstract

Background: Recognizing the cause of optic neuritis (ON) affects treatment decisions and visual outcomes. Objective: We aimed to define radiological features of first-episode demyelinating ON. Methods: We performed blinded radiological assessment of 50 patients presenting with first-episode myelin oligodendrocyte glycoprotein (MOG) antibody-associated ON (MOG-ON; n=19), aquaporin-4 (AQP4) antibody-associated ON (AQP4-ON; n=11), multiple sclerosis (MS)-associated ON (MS-ON; n=13), and unclassified ON ( n=7). Results: Bilateral involvement was more common in MOG-ON and AQP4-ON than MS-ON (84% vs. 82% vs. 23%), optic nerve head swelling was more common in MOG-ON (53% vs. 9% vs. 0%), chiasmal involvement was more common in AQP4-ON (5% vs. 64% vs. 15%), and bilateral optic tract involvement was more common in AQP4-ON (0% vs. 45% vs. 0%). Retrobulbar involvement was more common in MOG-ON, whereas intracranial involvement was more common in AQP4-ON. MOG-ON and AQP4-ON had longer lesion lengths than MS-ON. The combination of two predictors, the absence of magnetic resonance imaging brain abnormalities and a higher lesion extent score, showed a good ability to discriminate between an autoantibody-associated ON (MOG or AQP4) and MS. AQP4-ON more frequently had severe and sustained visual impairment. Conclusion: MOG-ON and AQP4-ON are more commonly bilateral and longitudinally extensive. MOG-ON tends to involve the anterior optic pathway, whereas AQP4-ON the posterior optic pathway.

Publisher

SAGE Publications

Subject

Clinical Neurology,Neurology

Link

http://journals.sagepub.com/doi/pdf/10.1177/1352458515593406

Reference31 articles.

1. Multiple sclerosis

2. Optic neuritis

3. A serum autoantibody marker of neuromyelitis optica: distinction from multiple sclerosis

4. IgG marker of optic-spinal multiple sclerosis binds to the aquaporin-4 water channel

5. Antibodies to native myelin oligodendrocyte glycoprotein in children with inflammatory demyelinating central nervous system disease

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