Active CMV infection in two patients with multiple sclerosis treated with alemtuzumab-Reference-Cited by-同舟云学术

Active CMV infection in two patients with multiple sclerosis treated with alemtuzumab

Published:2017-02-01 Issue:6 Volume:23 Page:874-876
ISSN:1352-4585
Container-title:Multiple Sclerosis Journal
language:en
Short-container-title:Mult Scler

Author:

Clerico Marinella¹,De Mercanti Stefania¹,Artusi Carlo Alberto¹,Durelli Luca¹,Naismith Robert T²

Affiliation:

1. Clinical and Biological Sciences Department, Neurology Unit, University of Torino, San Luigi Gonzaga Hospital, Orbassano, Italy

2. Department of Neurology, Washington University, St. Louis, MO, USA

Abstract

Alemtuzumab is a humanized monoclonal antibody targeting the surface molecule CD52, resulting in a rapid depletion of innate and adaptive immune cells. Infection rates in multiple sclerosis (MS) treatment trials were higher in alemtuzumab than in interferon beta–treated patients. We report two MS patients who developed cytomegalovirus disease within 1 month after the first 5-day cycle of alemtuzumab. Upon identification and appropriate treatment of the infection, each recovered completely. Neurologists should be aware of this serious but treatable complication.

Publisher

SAGE Publications

Subject

Neurology (clinical),Neurology

Link

http://journals.sagepub.com/doi/pdf/10.1177/1352458516688350

Reference10 articles.

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4. Alemtuzumab in Previously Treated Chronic Lymphocytic Leukemia Patients Who Also Had Received Fludarabine

5. Alemtuzumab versus interferon beta 1a as first-line treatment for patients with relapsing-remitting multiple sclerosis: a randomised controlled phase 3 trial

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