Altered lymphocyte profiles and herpes zoster infections in patients with multiple sclerosis on natalizumab-Reference-Cited by-同舟云学术

Altered lymphocyte profiles and herpes zoster infections in patients with multiple sclerosis on natalizumab

Published:2024-06-16 Issue: Volume: Page:
ISSN:1352-4585
Container-title:Multiple Sclerosis Journal
language:en
Short-container-title:Mult Scler

Author:

Balshi Alexandra¹^ORCID,Manning Nova¹,Dempsey John¹^ORCID,Kumbar Sachin¹,Baber Ursela¹,Sloane Jacob A¹^ORCID

Affiliation:

1. Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA

Abstract

Cases of herpes zoster (HZ) in patients with MS on natalizumab (NTZ) have been documented. In this study, we assessed lymphocyte subsets in NTZ-treated patients with HZ compared to matched controls without HZ. Twenty unvaccinated patients developed HZ while on NTZ for an incidence rate of 12.3 per 1000 patient-years. These patients had lower CD8+% and higher CD4+:CD8+ ratios ( p ⩽ 0.01) than non-HZ matched controls. Two patients with relapsing-remitting MS developed HZ twice while on NTZ. These findings underscore the importance of pre-NTZ HZ vaccination due to potential HZ risk.

Publisher

SAGE Publications

Link

https://journals.sagepub.com/doi/pdf/10.1177/13524585241260537

Reference9 articles.

1. A Randomized, Placebo-Controlled Trial of Natalizumab for Relapsing Multiple Sclerosis

2. Three cases of herpes zoster radiculitis in MS patients treated with natalizumab

3. Report of Three Cases of Herpes Zoster During Treatment with Natalizumab

4. Varicella zoster-associated acute retinal necrosis and central nervous system complications in natalizumab treated MS patients

5. Varicella-zoster meningovasculitis in a multiple sclerosis patient treated with natalizumab