The NAIMS cooperative pilot project: Design, implementation and future directions

Author:

Oh Jiwon1,Bakshi Rohit2,Calabresi Peter A3,Crainiceanu Ciprian3,Henry Roland G4,Nair Govind5,Papinutto Nico4,Constable R Todd6,Reich Daniel S5,Pelletier Daniel7,Rooney William8,Schwartz Daniel8,Tagge Ian8,Shinohara Russell T9,Simon Jack H8,Sicotte Nancy L10,

Affiliation:

1. Division of Neurology, University of Toronto, Toronto, ON, Canada/Department of Neurology and Neurosurgery, Johns Hopkins University, Baltimore, MD, USA

2. Laboratory for Neuroimaging Research, Partners Multiple Sclerosis Center, Departments of Neurology and Radiology, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USA

3. Department of Neurology and Neurosurgery, Johns Hopkins University, Baltimore, MD, USA

4. Department of Neurology, University of California, San Francisco, San Francisco, CA, USA

5. Translational Neuroradiology Unit, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Rockville, MD, USA

6. Departments of Diagnostic Radiology and Neurosurgery, Yale University, New Haven, CT, USA

7. Department of Neurology, University of Southern California, Los Angeles, CA, USA

8. Advanced Imaging Research Center, Oregon Health & Science University, Portland, OR, USA

9. Department of Biostatistics and Epidemiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA

10. Department of Neurology, Cedars-Sinai Medical Center, The North American Imaging in Multiple Sclerosis (NAIMS), Los Angeles, CA, USA

Abstract

The North American Imaging in Multiple Sclerosis (NAIMS) Cooperative represents a network of 27 academic centers focused on accelerating the pace of magnetic resonance imaging (MRI) research in multiple sclerosis (MS) through idea exchange and collaboration. Recently, NAIMS completed its first project evaluating the feasibility of implementation and reproducibility of quantitative MRI measures derived from scanning a single MS patient using a high-resolution 3T protocol at seven sites. The results showed the feasibility of utilizing advanced quantitative MRI measures in multicenter studies and demonstrated the importance of careful standardization of scanning protocols, central image processing, and strategies to account for inter-site variability.

Publisher

SAGE Publications

Subject

Neurology (clinical),Neurology

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