Association of daily physical activity with brain volumes and cervical spinal cord areas in multiple sclerosis-Reference-Cited by-同舟云学术

Association of daily physical activity with brain volumes and cervical spinal cord areas in multiple sclerosis

Published:2022-12-27 Issue:3 Volume:29 Page:363-373
ISSN:1352-4585
Container-title:Multiple Sclerosis Journal
language:en
Short-container-title:Mult Scler

Author:

Block Valerie J¹^ORCID,Cheng Shuiting²,Juwono Jeremy²,Cuneo Richard²,Kirkish Gina²,Alexander Amber M²,Khan Mahir²^ORCID,Akula Amit²,Caverzasi Eduardo³,Papinutto Nico²,Stern William A²,Pletcher Mark J⁴,Marcus Gregory M⁵,Olgin Jeffrey E⁵,Hauser Stephen L²^ORCID,Gelfand Jeffrey M²,Bove Riley²^ORCID,Cree Bruce AC²^ORCID,Henry Roland G⁶

Affiliation:

1. UCSF Weill Institute for Neurosciences, Department of Neurology, University of California San Francisco, San Francisco, CA, USA/Department of Physical Therapy and Rehabilitation Science, University of California San Francisco, San Francisco, CA, USA

2. UCSF Weill Institute for Neurosciences, Department of Neurology, University of California San Francisco, San Francisco, CA, USA

3. UCSF Weill Institute for Neurosciences, Department of Neurology, University of California San Francisco, San Francisco, CA, USA/Department of Brain and Behavioral Sciences, University of Pavia, Pavia, Italy

4. Department of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, CA, USA/Department of Medicine, University of California San Francisco, San Francisco, CA, USA

5. Department of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, CA, USA

6. UCSF Weill Institute for Neurosciences, Department of Neurology, University of California San Francisco, San Francisco, CA, USA/Department of Radiology, University of California San Francisco, San Francisco, CA, USA

Abstract

Background: Remote activity monitoring has the potential to evaluate real-world, motor function, and disability at home. The relationships of daily physical activity with spinal cord white matter and gray matter (GM) areas, multiple sclerosis (MS) disability and leg function, are unknown. Objective: Evaluate the association of structural central nervous system pathology with ambulatory disability. Methods: Fifty adults with progressive or relapsing MS with motor disability who could walk >2 minutes were assessed using clinician-evaluated, patient-reported outcomes, and quantitative brain and spinal cord magnetic resonance imaging (MRI) measures. Fitbit Flex2, worn on the non-dominant wrist, remotely assessed activity over 30 days. Univariate and multivariate analyses were performed to assess correlations between physical activity and other disability metrics. Results: Mean age was 53.3 years and median Expanded Disability Status Scale (EDSS) was 4.0. Average daily step counts (STEPS) were highly correlated with EDSS and walking measures. Greater STEPS were significantly correlated with greater C2-C3 spinal cord GM areas (ρ = 0.39, p = 0.04), total cord area (TCA; ρ = 0.35, p = 0.04), and cortical GM volume (ρ = 0.32, p = 0.04). Conclusion These results provide preliminary evidence that spinal cord GM area is a neuroanatomical substrate associated with STEPS. STEPS could serve as a proxy to alert clinicians and researchers to possible changes in structural nervous system pathology.

Funder

Foundation for the National Institutes of Health

National Multiple Sclerosis Society Lone Star

Valhalla Foundation

U.S. Department of Defense

National Multiple Sclerosis Society

Friends of the Multiple Sclerosis Research Group at UCSF

Publisher

SAGE Publications

Subject

Neurology (clinical),Neurology

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