Epstein–Barr virus-specific adoptive immunotherapy for progressive multiple sclerosis-Reference-Cited by-同舟云学术

Epstein–Barr virus-specific adoptive immunotherapy for progressive multiple sclerosis

Published:2014-02-03 Issue:11 Volume:20 Page:1541-1544
ISSN:1352-4585
Container-title:Multiple Sclerosis Journal
language:en
Short-container-title:Mult Scler

Author:

Pender Michael P¹²,Csurhes Peter A¹³,Smith Corey²,Beagley Leone²,Hooper Kaye D¹⁴,Raj Meenakshi⁴,Coulthard Alan¹⁵,Burrows Scott R¹²,Khanna Rajiv¹²

Affiliation:

1. The University of Queensland, School of Medicine, Brisbane, Queensland, Australia

2. QIMR Centre for Immunotherapy and Vaccine Development and Department of Immunology, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia

3. The University of Queensland Centre for Clinical Research, Brisbane, Queensland, Australia

4. Department of Neurology, Royal Brisbane and Women’s Hospital, Brisbane, Queensland, Australia

5. Department of Medical Imaging, Royal Brisbane and Women’s Hospital, Brisbane, Queensland, Australia

Abstract

Defective control of Epstein–Barr virus (EBV) infection by cytotoxic CD8+ T cells might predispose to multiple sclerosis (MS) by allowing EBV-infected autoreactive B cells to accumulate in the central nervous system. We have treated a patient with secondary progressive MS with in vitro-expanded autologous EBV-specific CD8+ T cells directed against viral latent proteins. This adoptive immunotherapy had no adverse effects and the patient showed clinical improvement with reduced disease activity on magnetic resonance imaging and decreased intrathecal immunoglobulin production. This is the first report of the use of EBV-specific adoptive immunotherapy to treat MS or any other autoimmune disease.

Publisher

SAGE Publications

Subject

Neurology (clinical),Neurology

Link

http://journals.sagepub.com/doi/pdf/10.1177/1352458514521888

Reference10 articles.

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3. Infection of autoreactive B lymphocytes with EBV, causing chronic autoimmune diseases

4. Decreased T cell reactivity to Epstein-Barr virus infected lymphoblastoid cell lines in multiple sclerosis

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