Therapeutic Potential of Kalanchoe Species: Flavonoids and other Secondary Metabolites

Abstract

The Kalanchoe genus (syn. Bryophyllum), family Crassulaceae, comprises 125 species, most of them native to Madagascar. The great importance of several of these species for the traditional medicine in several regions of the World, esspecially India, Africa, China and Brazil, stimulated research programs into these plants from both a pharmacological and chemical point of view. The present review focuses on the main results obtained during the last decade on the secondary metabolites isolated from these species – endowed or not with a specific biological profile – with emphasis on flavonoids. The distribution of these molecules in the genus will be summarized and special attention will be given to K. brasiliensis and K. pinnata, two species well-known for healing inflammatory and infectious processes. Ornamental Kalanchoe species are also discussed as a potential source of bioactive compounds. This review covers the period 1970–2008.