Antiparasitic and Anticancer Constituents of the Endophytic Fungus Aspergillus sp. strain F1544-Reference-Cited by-同舟云学术

Antiparasitic and Anticancer Constituents of the Endophytic Fungus Aspergillus sp. strain F1544

Published:2012-02 Issue:2 Volume:7 Page:1934578X1200700
ISSN:1934-578X
Container-title:Natural Product Communications
language:en
Short-container-title:Natural Product Communications

Author:

Martínez-Luis Sergio¹,Cherigo Lilia²,Arnold Elizabeth³,Spadafora Carmenza⁴,Gerwick William H.⁵,Cubilla-Rios Luis²

Affiliation:

1. Center for Drug Discovery, Institute for Advanced Scientific Research and High Technology Services, City of Knowledge, PO Box 0843-01103, Panama

2. Laboratory of Tropical Bioorganic Chemistry, University of Panama, Panama City, Apartado 0824-00159, Panama

3. Division of Plant Pathology and Microbiology, University of Arizona, Tucson, Arizona 85721, USA

4. Center for Cellular & Molecular Biology of Diseases, Institute for Advanced Scientific Research and High Technology Services, City of Knowledge, PO Box 0843-01103, Panama

5. Center for Marine Biotechnology and Biomedicine, University of California San Diego, La Jolla, California 92093, USA

Abstract

With the combined goal of finding the best anti-parasitic and anti-cancer activities as well as isolating the bioactive agents and studying their structures and biological properties, we proceeded to perform a small-scale cultivation of Aspergillus sp. strain F1544 using Potato Dextrose, Malt Extract, Czapek Dox and Eight Vegetables media. From the more promising extracts (obtaining using potato dextrose and czapek dox media in large scale) of this fungus, we isolated the five compounds: pseurotin A (1), 14-norpseurotin A (2), FD-838 (3), and pseurotin D (4), and fumoquinone B (5). All compounds showed good antileishmanial and moderate anticancer activities.

Publisher

SAGE Publications

Subject

Complementary and alternative medicine,Plant Science,Drug Discovery,Pharmacology,General Medicine

Link

http://journals.sagepub.com/doi/pdf/10.1177/1934578X1200700207

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