Affiliation:
1. Institute of Modern Chinese Medicine (IMCM), College of Pharmaceutical Sciences, Zhejiang University, 388 Yuhangtang Rd., Hangzhou, P. R. China 310058
2. Zhejiang Chem-Tech Group Co., Ltd., 387 Tianmushan Rd., Hangzhou, P. R. China 310023
Abstract
Eight alkaloids, including a new compound, (+)-norboldine acetate (1), and seven known ones, (+)-norboldine (2), (+)-boldine (3), (+)-laurotetanine (4), (+)- N-methyllaurotetanine (5), (+)-reticuline (6), (–)-pronuciferine (7), and pallidine (8) were isolated from the roots of Lindera aggregata. The structures of these alkaloids were determined by spectroscopic and chemical methods, especially 2D NMR techniques, which also allowed the first full NMR assignments of alkaloids 2, 4 and 5. Among them, the 1D NMR chemical shifts of (+)-norboldine (2) showed a remarkable environmental sensitive behavior. All the alkaloids were tested in cytotoxicity assays against L1210 and K562 tumor cell lines; only (+)-norboldine (2) showed weak activity against the L1210 cell line.
Subject
Complementary and alternative medicine,Plant Science,Drug Discovery,Pharmacology,General Medicine
Cited by
10 articles.
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