Hepatitis-Associated (Australia) Antigen and Down's Syndrome

Author:

Shiono Hiroshi1,Kadowaki Junichi1,Fujiwara Takeki2,Nakao Tooru2

Affiliation:

1. Department of Pediatrics, National Nishi-Sapporo Hospital, Yamanote 5–8, Nishiku, Sapporo, Japan.

2. Department of Pediatrics, Sapporo Medical College, Sapporo, Japan.

Abstract

Hepatitis-Associated (Australia) Antigen (HAA) was detected in 13 (5.8%) of 223 patients with Down's syndrome and in 14 (3.7%) of 378 patients with other forms of mental retardation. The frequency of HAA was 2.4 per cent in 127 noninstitutionalized patients with Down's syndrome, and 10.4 per cent in 96 institutionalized patients. The frequency of HAA with Down's syndrome was lower on the average in Japan than in the United States or Germany. HAA was detected in one (1.3%) of 78 mothers of infants with Down's syndrome. Our study suggests that maternal exposure to HAA, as reflected by the presence of either HAA or anti-HAA, was not associated with the subsequent birth of an infant with Down's syndrome.

Publisher

SAGE Publications

Subject

Pediatrics, Perinatology and Child Health

Cited by 1 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. Prenatal diagnosis, pregnancy terminations and prevalence of Down syndrome in Atlanta;Birth Defects Research Part A: Clinical and Molecular Teratology;2004

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