Lactose-Free Milk Protein-Based Infant Formula: Impact on Growth and Gastrointestinal Tolerance in Infants

Author:

Lasekan John B.1,Jacobs Joan2,Reisinger Keith S.3,Montalto Michael B.2,Frantz Mary P.2,Blatter Mark M.3

Affiliation:

1. Abbott Nutrition, Abbott Laboratories, Columbus, OH, USA,

2. Abbott Nutrition, Abbott Laboratories, Columbus, OH, USA

3. Primary Physicians Research, Inc, Pittsburgh, PA, USA

Abstract

Lactose, the major carbohydrate in human milk and standard milk—based formulas, provides energy for growth in infants. The use of lactose-free milk protein—based infant formulas has increased in the United States. However, clinical studies of their impact on growth, safety, and gastrointestinal tolerance in infants are limited. Thus, a prospective, blinded, randomized clinical trial was conducted in healthy, normal-term infants fed an experimental lactose-free milk protein—based formula (NoLAC; n = 63) versus a standard commercial lactose-containing milk-based formula (LAC; n = 65) for 112 days. Growth (weight, length, and head circumference) was similar and normal in both groups (weight gain: NoLAC = 31.1 ± 0.9 g/day, LAC = 29.4 ± 0.9 g/day, mean ± SEM; P = .895). Serum biochemistries for both groups were within infants’ normal reference ranges. Both groups had comparable tolerance but the NoLAC group had softer stools and lower spit-ups. Thus, the study suggests that absence of lactose in milk-based formula does not adversely affect normal growth in term infants.

Publisher

SAGE Publications

Subject

Pediatrics, Perinatology, and Child Health

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