Isolated Balanced Complete Atrioventricular Septal Defects: Prenatal Detection and Outcome in Nevada

Author:

Evans William N.12,Acherman Ruben J.12,Ciccolo Michael L.13,Lehoux Juan1,Restrepo Humberto12ORCID

Affiliation:

1. Children’s Heart Center Nevada, Las Vegas, NV, USA

2. Department of Pediatrics, Division of Pediatric Cardiology, Kirk Kerkorian School of Medicine at University of Nevada Las Vegas, Las Vegas, NV, USA

3. Department of Surgery, Kirk Kerkorian School of Medicine at University of Nevada Las Vegas, Las Vegas, NV, USA

Abstract

We analyzed patients with isolated, balanced complete atrioventricular septal defects. We identified 71 patients born in Nevada, between January 2008 and December 2020. We also analyzed prenatal detection rates. Of the 71, 61 (85%) had trisomy 21, 1 (1%) had CHARGE syndrome and 22q.11 deletion, and 10 (14%) had no chromosomal abnormalities. Of the 71, 67 had prenatal care, and 43/67 (64%) were prenatally diagnosed. Prenatal detection rate for 2008-2012 was 9/20 (45%) and 18/21 (86%) for 2018-2020, P = .03. Of the 71, 67 underwent surgical repair with 1 current postpulmonary artery banding and 0 surgical deaths. Of the 67, 3 (4%) had heart block. Only 1 (1.5%) patient had reoperation for a mitral valve replacement. Of the 71, 67 (94%) are alive during a 6-year average (range = 0-12 years) follow-up. In conclusion, surgical and long-term outcomes were excellent. Also, high state-wide, general population prenatal detection rates were achieved.

Publisher

SAGE Publications

Subject

Pediatrics, Perinatology and Child Health

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