Affiliation:
1. Department of Pediatrics, Tripler Army Medical Center, Department of Pediatrics, University of Hawaii School of Medicine, Honolulu, Hawaii
Abstract
Twenty children, while hospitalized with pneu monia, were treated by randomization with graded dosages of oral ampicillin; five each received 50, 100, 150, or 200 mg/kg daily in four equally divided doses for at least five days. The peak serum levels rose from a mean of 1 mcg/ml with 50 mg/kg per day to 4 to 7 mcg/ml with 200 mg/kg per day. Mild to moderate diarrhea, encountered in two of the five patients of each study group, was apparently unrelated to dose, and did not hinder absorption of the drug to a clinically significant degree.
Subject
Pediatrics, Perinatology and Child Health
Cited by
4 articles.
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1. Antimicrobial Therapy;Pediatric Infectious Diseases for the Practitioner;1985
2. Pharmacokinetics of bacampicillin in infants;Journal of Antimicrobial Chemotherapy;1978
3. Arthritis associated with ampicillin colitis;Archives of Internal Medicine;1977-11-01
4. Colitis and diarrhoea: A problem with antibiotic therapy;British Journal of Surgery;1976-04