Lessons from autopsy: Topographical variability of atherosclerosis plaques

Author:

Faa Gavino12,Cau Riccardo3ORCID,Ravarino Alberto4,Canino Andrea4,Van Eyken Peter5,Fraschini Matteo6,Suri Jasjit S7,Saba Luca3

Affiliation:

1. Department of Medical Sciences, University of Cagliari, Cagliari, Italy

2. Department of Biology, College of Science and Technology, Temple University, Philadelphia, PA, USA

3. Department of Medical Sciences and Public Health, Unit of Radiology, University of Cagliari, Cagliari, Italy

4. Division of Pathology, AOU of Cagliari, Cagliari, Italy

5. Division of Pathology, Genk Regional Hospital, Genk, Belgium

6. Department of Electrical and Eletronic Engineering, University of Cagliari, Cagliari, Italy

7. Stroke Diagnostic and Monitoring Division, Atheropoint, Roseville, CA, USA

Abstract

Atherosclerosis is a complex disease characterized by the accumulation of plaques in arterial walls. Understanding its pathogenesis remains incomplete, with factors like inflammation, oxidative stress, and hypertension playing critical roles. The disease exhibits preferential localization of plaques, with variability observed even within the same individual. Genetic, environmental, and lifestyle factors contribute to its heterogeneity. Histological plaque phenotypes vary widely, prompting classification schemes focusing on systemic and local factors deteriorating fibrous caps. Recent research highlights differences in plaque histology among arterial systems, suggesting unique pathophysiological mechanisms. This study reports on multiple atherosclerotic plaques detected at autopsy in various vascular sites of a single subject, emphasizing their histological diversity and underscoring the systemic nature of atherosclerosis.

Publisher

SAGE Publications

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