IL-37 (IL-1F7) the Newest Anti-Inflammatory Cytokine Which Suppresses Immune Responses and Inflammation-Reference-Cited by-同舟云学术

IL-37 (IL-1F7) the Newest Anti-Inflammatory Cytokine Which Suppresses Immune Responses and Inflammation

Published:2012-01 Issue:1 Volume:25 Page:31-38
ISSN:2058-7384
Container-title:International Journal of Immunopathology and Pharmacology
language:en
Short-container-title:Int J Immunopathol Pharmacol

Author:

Tetè S.¹,Tripodi D.¹,Rosati M.²,Conti F.²,Maccauro G.³,Saggini A.⁴,Cianchetti E.⁵,Caraffa A.⁶,Antinolfi P.⁶,Toniato E.⁷,Castellani M.L.⁷,Conti P.⁷,Theoharides T.C.⁸

Affiliation:

1. Dental School, University of Chieti-Pescara, Italy

2. Gynecology Division, Pescara Hospital, Pescara, Italy

3. Department of Orthopedics, Catholic University of Rome, Rome, Italy

4. Department of Dermatology, University of Rome Tor Vergata, Rome, Italy

5. Ortona Hospital, University of Chieti-Pescara, Italy

6. Department of Orthopedics, University of Perugia, Perugia, Italy

7. Immunology Division, University of Chieti-Pescara, Italy

8. Department of Physiology and Pharmacology, Tufts University School of Medicine, New England Medical Center, Boston, MA, USA

Abstract

Cytokines such as interleukins, chemokines and interferons are immunomodulating and inflammatory agents, characterized by considerable redundancy, in that many cytokines appear to share similar functions. Virtually all nucleated cells, but especially epithelial cells and macrophages, are potent producers of cytokines. The objective of this study is to review the detailed mechanism of action and the biological profiles of IL-37, the newest anti-inflammatory cytokine. This review focuses on IL-37, a key cytokine in regulating inflammatory responses, mainly by inhibiting the expression, production and function of proinflammatory cytokines: IL-1 family pro-inflammatory effects are markedly suppressed by IL-37.

Publisher

SAGE Publications

Subject

Pharmacology,Immunology,Immunology and Allergy

Link

http://journals.sagepub.com/doi/pdf/10.1177/039463201202500105

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