The Interferons in Clinical Practice

Abstract

In the last decade, recombinant DNA technologies have allowed the production of highly purified interferons in virtually unlimited amounts. Therefore it has become possible to evaluate the usefulness of interferon therapy in several different diseases. Nowadays interferons have a well defined role in the therapy of infectious and malignant diseases. As these natural modifiers of biological responses are widely available to the specialist and to the general practitioner as well, in the present paper we review the main biochemical properties and the molecular mechanisms underlying the heterogeneous activities of the interferons. Furthermore, on the basis of already published therapeutical trials, we indicate the infectious and neoplastic diseases in which therapy with interferon has been effective and outline the most frequent toxic or side effects of this therapy.