IL-36 Receptor Antagonist with Special Emphasis on IL-38-Reference-Cited by-同舟云学术

IL-36 Receptor Antagonist with Special Emphasis on IL-38

Published:2013-01 Issue:1 Volume:26 Page:27-36
ISSN:2058-7384
Container-title:International Journal of Immunopathology and Pharmacology
language:en
Short-container-title:Int J Immunopathol Pharmacol

Author:

Shaik Y.¹,Sabatino G.²,Maccauro G.³,Varvara G.⁴,Murmura G.⁴,Saggini A.⁵,Rosati M.⁶,Conti F.⁶,Cianchetti E.⁷,Caraffa A.⁸,Antinolfi P.⁸,Pandolfi F.⁹,Potalivo G.⁸,Galzio R.¹⁰,Conti P.¹¹,Theoharides T.C.¹²

Affiliation:

1. Department of Medicine, Boston University School of Medicine, Boston, MA, USA

2. Neonatology Division, University of Chieti, Italy

3. Department of Orthopedics, Catholic University of Rome, Italy

4. Dental School, University of Chieti-Pescara, Italy

5. Department of Dermatology, University of Rome Tor Vergata, Rome, Italy

6. Gynecology Division, Pescara Hospital, Pescara, Italy

7. Ortona Hospital, University of Chieti-Pescara, Italy

8. Orthopeadics Division, University of Perugia, Perugia Italy

9. Department of Internal Medicine, Catholic University of the Sacred Heart, Rome, Italy

10. Department of Health Sciences, University of L ‘Aquila, Italy

11. Immunology Division, Department of Experimental and Clinical Sciences, University of Chieti, Italy

12. Department of Pharmacology and Experimental Therapeutics, Biochemistry and Internal Medicine Tufts University School of Medicine, Tufts-New England Medical Center, Boston, MA, USA

Abstract

IL-36 is another family member of IL-1 and induces the production of proinflammatory cytokines and activates MAPK and NFκB pathways. IL-36 is a common mediator of innate and adaptive immune response and is inhibited by IL-36 receptor antagonist (RA). IL-36RA acts on IL-36 receptor ligand which exerts proinflammatory effect in vivo and in vitro. IL-38 binds to IL-36 receptor as does IL-36RA and has similar biological effects on immune cells. IL-38 is also a member of IL-1 cytokine and shares some characteristics of IL-1RA, binding the same IL-1 receptor type I. IL-38 plays a role in the pathogenesis of inflammatory diseases, exerting protective effect in some autoimmune diseases. Both IL-38 and IL-36RA have an anti-inflammatory biological effect, however in some cases have contrary effects.

Publisher

SAGE Publications

Subject

Pharmacology,Immunology,Immunology and Allergy

Link

http://journals.sagepub.com/doi/pdf/10.1177/039463201302600103

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