Cholesterol, Cytokines and Diseases-Reference-Cited by-同舟云学术

Cholesterol, Cytokines and Diseases

Published:2011-07 Issue:3 Volume:24 Page:567-581
ISSN:2058-7384
Container-title:International Journal of Immunopathology and Pharmacology
language:en
Short-container-title:Int J Immunopathol Pharmacol

Author:

Saggini A.¹,Anogeianaki A.²,Maccauro G.³,Teté S.⁴,Salini V.⁵,Caraffa A.⁶,Conti F.⁷,Fulcheri M.⁸,Galzio R.⁹,Shaik-Dasthagirisaheb Y.B.¹⁰

Affiliation:

1. Department of Dermatology, University of Rome Tor Vergata, Rome, Italy

2. Physiology Department, School of Medicine, Aristotle University of Thessaloniki, Greece

3. Department of Orthopaedics, Catholic University of Rome, Rome, Italy

4. School of Dentistry, University of Chieti, Italy

5. Orthopaedics Division, University of Chieti, Chieti, Italy

6. Orthopaedics Division, University of Perugia, Perugia, Italy

7. Department of Gyneacology, “Santo Spirito” Hospital, Pescara, Italy

8. Department of Clinical Psychology, University of Chieti, Italy

9. Department of Health Sciences, University of L'Aquila, Italy

10. Department of Medicine, Boston University School of Medicine, Boston, MA, USA

Abstract

A high level of cholesterol is associated with obesity, cardiovascular diseases and atherosclerosis. Immune response in atherosclerosis is mediated by chemokines which attract monocytes, leading to the innate immune response characterised by the production of cytokines. The immunoregulatory cytokines are an important bridge between innate and adductive immunity. TH1 cytokines are involved as effector T cells in inflammatory response, while TH2 cytokines can be anti-inflammatory such as IL-10 and IL-4. It is well known that statins enhance the production of TH2 cytokines whereas the secretion of TH1 cytokines is suppressed. For this purpose, we studied the significance of anti-inflammatory effect and suppression of inflammation by statins. In this paper we revisited the role of cholesterol and cytokines IL-18, IL-10, IL-12, TNF-α, interferon-γ, and chemokines in inflammatory diseases.

Publisher

SAGE Publications

Subject

Pharmacology,Immunology,Immunology and Allergy

Link

http://journals.sagepub.com/doi/pdf/10.1177/039463201102400303

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