Cutting Edge: Lymphoproliferative Disease in the Absence of CTLA-4 Is Not T Cell Autonomous-Reference-Cited by-同舟云学术

Cutting Edge: Lymphoproliferative Disease in the Absence of CTLA-4 Is Not T Cell Autonomous

Published:1999-08-01 Issue:3 Volume:163 Page:1128-1131
ISSN:0022-1767
Container-title:The Journal of Immunology
language:en
Short-container-title:

Author:

Bachmann Martin F.¹,Köhler Gabriele²,Ecabert Barbara¹,Mak Tak W.³,Kopf Manfred¹

Affiliation:

1. *Basel Institute for Immunology, Basel, Switzerland;

2. †Department of Pathology, University of Freiburg, Freiburg, Germany; and

3. ‡Amgen Institute, Toronto, Ontario, Canada

Abstract

AbstractMice deficient for the expression of CTLA-4 develop a lethal lymphoproliferative syndrome and multiorgan inflammation leading to death at about 4 wk of age. Here we show that RAG2-deficient mice reconstituted with CTLA-4-deficient bone marrow do not develop a lymphoproliferative syndrome despite lymphocyte infiltration mainly into pericardium and liver. Moreover, RAG2-deficient mice reconstituted with a mixture of normal and CTLA-4-deficient bone marrow remain healthy and do not develop any disease. Thus, the lethal disease observed in CTLA-4-deficient mice is not T cell autonomous and can be prevented by factors produced by normal T cells.

Publisher

The American Association of Immunologists

Subject

Immunology,Immunology and Allergy

Link

https://journals.aai.org/jimmunol/article-pdf/163/3/1128/1107294/im159901128p.pdf

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