S100A9: The Unusual Suspect Connecting Viral Infection and Inflammation-Reference-Cited by-同舟云学术

S100A9: The Unusual Suspect Connecting Viral Infection and Inflammation

Published:2024-05-15 Issue:10 Volume:212 Page:1523-1529
ISSN:0022-1767
Container-title:The Journal of Immunology
language:en
Short-container-title:

Author:

Boucher Julien¹²,Gilbert Caroline¹²^ORCID,Bose Santanu³,Tessier Philippe A.¹²

Affiliation:

1. *Axe de Recherche sur les Maladies Infectieuses et Immunitaires, Centre de Recherche du CHU de Québec–Université Laval, Quebec City, Quebec, Canada

2. †Département de Microbiologie-Infectiologie et d’Immunologie, Faculté de Médecine, Université Laval, Quebec City, Quebec, Canada

3. ‡Department of Veterinary Microbiology and Pathology, College of Veterinary Medicine, Washington State University, Pullman, WA

Abstract

Abstract The study of S100A9 in viral infections has seen increased interest since the COVID-19 pandemic. S100A8/A9 levels were found to be correlated with the severity of COVID-19 disease, cytokine storm, and changes in myeloid cell subsets. These data led to the hypothesis that S100A8/A9 proteins might play an active role in COVID-19 pathogenesis. This review explores the structures and functions of S100A8/9 and the current knowledge on the involvement of S100A8/A9 and its constituents in viral infections. The potential roles of S100A9 in SARS-CoV-2 infections are also discussed.

Funder

Canadian Government | CIHR | CIHR Skin Research Training Centre

HHS | NIH | Office of Extramural Research

Publisher

The American Association of Immunologists

Link

https://journals.aai.org/jimmunol/article-pdf/212/10/1523/1656629/ji2300640.pdf

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